Sloth

Sloth is an OS X application that displays a list of all open files and sockets in use by all running applications on your system. This makes it easy to see which apps are using which files and sockets.

Sloth is basically a GUI application on top of the powerful lsof command line tool. The output of lsof is parsed and shown in a searchable, filterable table view with some convenient user-friendly functionality such as revealing files in the Finder, killing a file's owning process, etc.

You can download the app here:

Sloth is free, open source software and has a home on GitHub.

Screenshot

sloth screenshot1
sloth screenshot2